Prior to motor symptom onset or neuronal cell loss in HD, levels of the type 1 cannabinoid receptor (CB1) decrease in the basal ganglia. Decreasing CB1 levels are strongly correlated with chorea and cognitive deficit. 2-AG and AEA normalized CB1 protein levels and improved cell viability, whereas CP55,940 and THC reduced CB1 protein levels and cell viability in HD cells.
Possibility of efficacy for cannabis in treatment of Huntington's Disease according to the results found in this study.
2-arachidonoylglycerol (2-AG), anandamide (AEA), CP55,940, Δ(9)-tetrahydrocannabinol (THC), cannabidiol (CBD), and THC+CBD (1:1)