Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability In A Cell Culture Model Of Huntington Disease

Huntington's Disease

Key Findings

Prior to motor symptom onset or neuronal cell loss in HD, levels of the type 1 cannabinoid receptor (CB1) decrease in the basal ganglia. Decreasing CB1 levels are strongly correlated with chorea and cognitive deficit. 2-AG and AEA normalized CB1 protein levels and improved cell viability, whereas CP55,940 and THC reduced CB1 protein levels and cell viability in HD cells.

Information and Links


Link: Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability In A Cell Culture Model Of Huntington Disease

Year: 2016

DOI: 10.1124/mol.115.101980


Ratings

(How Ratings Work)

Huntington's Disease — 1


Possibility of efficacy for cannabis in treatment of Huntington's Disease according to the results found in this study.

Drugs Used

WIN55,212-2

2-arachidonoylglycerol (2-AG), anandamide (AEA), CP55,940, Δ(9)-tetrahydrocannabinol (THC), cannabidiol (CBD), and THC+CBD (1:1)