We conclude that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
Link: Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Year: 2007
DOI: 10.1038/nn1916
Possible to probable range of efficacy of cannabis for treatment of Pain (Neuropathies, in general) according to the results found in this study.
Cannabinoid receptor CB1 studied