A Multicenter Dose-escalation Study of the Analgesic and Adverse Effects of an Oral Cannabis Extract (Cannador) for Postoperative Pain Management

Pain (Acute)

Key Findings

The first 11 patients at the 5-mg dose all requested rescue analgesia, so the dose was considered to provide inadequate analgesia and was stopped. For the 10-mg dose, only 6 of the first 14 patients required rescue analgesia, so recruitment continued for 30 patients. At 15 mg, 3 of the first 14 patients required rescue analgesia, and recruitment was subsequently stopped according to the predetermined protocol when the 24th patient had a serious adverse event. The optimal dose was determined to be 10 mg Cannador (oral cannabis gel capsules) because it was effective in providing pain relief at rest without serious or severe side effects in a fit adult group of postsurgical patients.

Information and Links


Link: A Multicenter Dose-escalation Study of the Analgesic and Adverse Effects of an Oral Cannabis Extract (Cannador) for Postoperative Pain Management

Year: 2006


Ratings

(How Ratings Work)

Pain (Acute) — 4


Probability toward demonstrable efficacy of cannabis for treatment of Pain (Acute) according to the results found in this study.

Drugs Used

THC and CBD extracts were in the ratio of 1:0.3 for the 5-mg dose group and 1:0.5 for the other groups.