A Selective Review Of Medical Cannabis In Cancer Pain Management

Pain (Due to Advanced Cancer)

Key Findings

A review of literature published on Medline between 1975 and 2017 identified five clinical studies that evaluated the effect of THC or CBD on controlling cancer pain, which have been reviewed and summarised. Five studies that evaluated THC oil capsules, THC:CBD oromucosal spray (nabiximols), or THC oromucosal sprays found some evidence of cancer pain reduction associated with these therapies. A variety of doses ranging from 2.7-43.2 mg/day THC and 0-40 mg/day CBD were administered. Higher doses of THC were correlated with increased pain relief in some studies. One study found that significant pain relief was achieved in doses as low as 2.7-10.8 mg THC in combination with 2.5-10.0 mg CBD, but there was conflicting evidence on whether higher doses provide superior pain relief. Some reported side effects include drowsiness, hypotension, mental clouding, and nausea and vomiting. There is evidence suggesting that medical cannabis reduces chronic or neu-ropathic pain in advanced cancer patients.

Information and Links


Link: A Selective Review Of Medical Cannabis In Cancer Pain Management

Year: 2017

DOI: 10.21037/apm.2017.08.05


Ratings

(How Ratings Work)

Pain (Due to Advanced Cancer) — 3


Likely probability of the efficacy of cannabis for treatment of Pain (Due to Advanced Cancer) according to the results found in this study.

Drugs Used

THC

CBD

Sativex