Amyloid Proteotoxicity Initiates An Inflammatory Response Blocked By Cannabinoids

Aging Alzheimer's Disease Parkinson's Disease Huntington's Disease

Key Findings

Cannabinoids such as tetrahydrocannabinol stimulate the removal of intraneuronal beta amyloid (Aβ), block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors.

Information and Links


Link: Amyloid Proteotoxicity Initiates An Inflammatory Response Blocked By Cannabinoids

Year: 2016

DOI: 10.1038/npjamd.2016.12


Ratings

(How Ratings Work)

Aging — 1


Possibility of efficacy for cannabis in treatment of Aging according to the results found in this study.

Alzheimer's Disease — 1


Possibility of efficacy for cannabis in treatment of Alzheimer's Disease according to the results found in this study.

Parkinson's Disease — 1


Possibility of efficacy for cannabis in treatment of Parkinson's Disease according to the results found in this study.

Huntington's Disease — 1


Possibility of efficacy for cannabis in treatment of Huntington's Disease according to the results found in this study.

Drugs Used

CB1 and CB2 receptors

Anandamide

AM404

UBR597

Q-3

AM281

AM251

AM630

THC

Arachidonic acid