Anandamide Decreases Naloxone-precipitated Withdrawal Signs In Mice Chronically Treated With Morphine

Addiction to Heroin Addiction to Opiod Based Pain Killers

Key Findings

Animals were chronically treated with increasing doses of morphine over 5 days. Typical signs of withdrawal (jumping and body weight loss) were examined after naloxone administration. In these conditions, anandamide (5 mg/kg, i.v.) decreased the expression of physical signs of opioid dependence.

Information and Links


Link: Anandamide Decreases Naloxone-precipitated Withdrawal Signs In Mice Chronically Treated With Morphine

Year: 1995


Ratings

(How Ratings Work)

Addiction to Heroin — 2


Possible to probable range of efficacy of cannabis for treatment of Addiction to Heroin according to the results found in this study.

Addiction to Opiod Based Pain Killers — 2


Possible to probable range of efficacy of cannabis for treatment of Addiction to Opiod Based Pain Killers according to the results found in this study.

Drugs Used

Delta-9-THC

Anandamide

Morphine

Narcan