Antinociceptive Effects Of HUF-101, A Fluorinated Cannabidiol Derivative

Pain (Acute)

Key Findings

Cannabidiol (CBD) is a phytocannabinoid with multiple pharmacological effects and several potential therapeutic properties. Its low oral bioavailability, however, can limit its clinical use. Preliminary results indicate that fluorination of the CBD molecule increases its pharmacological potency. The findings of this study show that HUF-101 produced antinociceptive effects at lower doses than CBD, indicating that the addition of fluoride improved its pharmacological profile. Furthermore, some of the antinociceptive effects of CBD and HUF-101 effects seem to involve the activation of CB1 and CB2 receptors.

Information and Links


Link: Antinociceptive Effects Of HUF-101, A Fluorinated Cannabidiol Derivative

Year: 2017

DOI: 10.1016/j.pnpbp.2017.07.012


Ratings

(How Ratings Work)

Pain (Acute) — 2


Possible to probable range of efficacy of cannabis for treatment of Pain (Acute) according to the results found in this study.

Drugs Used

HUF-101 (3, 10, and 30 mg/kg), a fluorinated CBD analogue. CBD (10, 30, and 90 mg/kg) and WIN55,212-2 (1, 3, and 5 mg/kg).