Attenuation Of Cue-induced Reinstatement Of Nicotine Seeking By URB597 Through Cannabinoid CB1 Receptor In Rats

Addiction to Nicotine

Key Findings

FAAH inhibition has been recently identified as having a critical involvement in behaviors related to nicotine addiction and has been shown to reduce the effect of nicotine on the mesolimbic dopaminergic system via CB1R and peroxisome proliferator-activated receptor alpha (PPARα). URB597 reduced cue-induced reinstatement of nicotine seeking.

Information and Links


Link: Attenuation Of Cue-induced Reinstatement Of Nicotine Seeking By URB597 Through Cannabinoid CB1 Receptor In Rats

Year: 2016

DOI: 10.1007/s00213-016-4232-y


Ratings

(How Ratings Work)

Addiction to Nicotine — 2


Possible to probable range of efficacy of cannabis for treatment of Addiction to Nicotine according to the results found in this study.

Drugs Used

The inhibitor of FAAH activity, URB597

AM630 and MK886