Bidirectional Effects Of Cannabidiol On Contextual Fear Memory Extinction

Post-Traumatic Stress Disorder

Key Findings

In summary, CBD had bidirectional effects on the extinction of contextual fear conditioning, depending on the nature of the initial fear conditioning. Nevertheless, in the more translationally-relevant stronger conditioning setting, CBD both acutely inhibited fear expression and enhanced extinction to produce longer lasting reductions in fear. These observations provide further support for the potential translational use of CBD in conditions such as posttraumatic stress disorder and specific phobias.

Information and Links


Link: Bidirectional Effects Of Cannabidiol On Contextual Fear Memory Extinction

Year: 2016

DOI: https://doi.org/10.3389/fphar.2016.00493


Ratings

(How Ratings Work)

Post-Traumatic Stress Disorder — 2


Possible to probable range of efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.

Drugs Used

Cannabidiol (10 mg/kg)

NMDA receptor antagonist MK-801