Brain Cannabinoid CB₂ Receptors Modulate Cocaine's Actions In Mice

Addiction to Crack or Cocaine

Key Findings

We found that systemic, intranasal or intra-accumbens local administration of JWH133, a selective CB(2) receptor agonist, dose-dependently inhibited intravenous cocaine self-administration. These findings suggest that brain CB(2) receptors modulate cocaine's rewarding and locomotor-stimulating effects, likely by a dopamine-dependent mechanism.

Information and Links


Link: Brain Cannabinoid CB₂ Receptors Modulate Cocaine's Actions In Mice

Year: 2011

DOI: 10.1038/nn.2874.


Ratings

(How Ratings Work)

Addiction to Crack or Cocaine — 2


Possible to probable range of efficacy of cannabis for treatment of Addiction to Crack or Cocaine according to the results found in this study.

Drugs Used

JWH133, a selective CB(2) receptor agonist