Cannabidiol Is A Partial Agonist At Dopamine D2High Receptors, Predicting Its Antipsychotic Clinical Dose

Schizophrenia

Key Findings

Cannabidiol at 800 mg/day was as clinically effective as amisulpride in alleviating the signs and symptoms of schizophrenia. 1000 mg per day cannabidiol added to the ongoing antipsychotic treatment significantly improved schizophrenia in a study on 88 patients. CBD had a biphasic effect with measured Ki values at 11 nM at dopamine D2High receptors and 2800 nM at dopamine at D2Low receptors.

Information and Links


Link: Cannabidiol Is A Partial Agonist At Dopamine D2High Receptors, Predicting Its Antipsychotic Clinical Dose

Year: 2016

DOI: 10.1038/tp.2016.195


Ratings

(How Ratings Work)

Schizophrenia — 2


Possible to probable range of efficacy of cannabis for treatment of Schizophrenia according to the results found in this study.

Drugs Used

CBD