Cannabidiol Regulation Of Emotion And Emotional Memory Processing: Relevance For Treating Anxiety-related And Substance Abuse Disorders

Post-Traumatic Stress Disorder Anxiety

Key Findings

Studies show that cannabidiol, the main non-psychotomimetic phytocannabinoid found in Cannabis sativa, reduces anxiety via 5-HT1A and (indirect) cannabinoid receptor activation in paradigms assessing innate responses to threat. There is also accumulating evidence from animal studies investigating the effects of cannabidiol on fear memory processing indicating that it reduces learned fear in paradigms that are translationally relevant to phobias and post-traumatic stress disorder. Cannabidiol does so by reducing fear expression acutely and by disrupting fear memory reconsolidation and enhancing fear extinction, both of which can result in a lasting reduction of learned fear. Recent studies have also begun to elucidate the effects of cannabidiol on drug memory expression using paradigms with translational relevance to addiction.

Information and Links


Link: Cannabidiol Regulation Of Emotion And Emotional Memory Processing: Relevance For Treating Anxiety-related And Substance Abuse Disorders

Year: 2017

DOI: 10.1111/bph.13724


Ratings

(How Ratings Work)

Post-Traumatic Stress Disorder — 3


Likely probability of the efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.

Anxiety — 3


Likely probability of the efficacy of cannabis for treatment of Anxiety according to the results found in this study.

Drugs Used

CBD