Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal

Addiction to Opiod Based Pain Killers Addiction to Heroin

Key Findings

Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and emotional symptoms. Research over the past decade has shed light on the influence of endocannabinoids on the opioid system. Evidence from both animal and clinical studies point towards an interaction between these two systems, and suggest that targeting the endocannabinoid system may provide novel interventions for managing opiate dependence and withdrawal. The findings from basic and pre-clinical studies in rodent models highlight several potential mechanisms through which cannabinoids may modulate the phenomenon of opioid withdrawal, and call attention to the importance of cannabinoid-opioid interactions within noradrenergic brain circuits such as the coeruleo-cortical pathway.

Information and Links


Link: Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal

Year: 2013

DOI: 10.1016/j.neuroscience.2013.04.034


Ratings

(How Ratings Work)

Addiction to Opiod Based Pain Killers — 3


Likely probability of the efficacy of cannabis for treatment of Addiction to Opiod Based Pain Killers according to the results found in this study.

Addiction to Heroin — 3


Likely probability of the efficacy of cannabis for treatment of Addiction to Heroin according to the results found in this study.

Drugs Used

Cannabinoids

Endocannabinoids