Cannabinoids And Neuroprotection In Basal Ganglia Disorders

Parkinson's Disease Huntington's Disease

Key Findings

Cannabinoids may provide neuroprotection in different neurodegenerative disorders including Parkinson's disease and Huntington's chorea, two chronic diseases that are originated as a consequence of the degeneration of specific nuclei of basal ganglia, resulting in a deterioration of the control of movement. There are two key mechanisms involved in the neuroprotection by cannabinoids in experimental models of these two disorders: first, a cannabinoid receptor-independent mechanism aimed at producing a decrease in the oxidative injury and second, an induction/upregulation of cannabinoid CB2 receptors, mainly in reactive microglia, that is capable to regulate the influence of these glial cells on neuronal homeostasis.

Information and Links


Link: Cannabinoids And Neuroprotection In Basal Ganglia Disorders

Year: 2007


Ratings

(How Ratings Work)

Parkinson's Disease — 3


Likely probability of the efficacy of cannabis for treatment of Parkinson's Disease according to the results found in this study.

Huntington's Disease — 3


Likely probability of the efficacy of cannabis for treatment of Huntington's Disease according to the results found in this study.

Drugs Used

Cannabinoids