Cannabinoids Prevent Depressive-like Symptoms And Alterations In BDNF Expression In A Rat Model Of PTSD

Post-Traumatic Stress Disorder Depression

Key Findings

Posttraumatic stress disorder (PTSD) is a debilitating condition highly comorbid with depression. The endocannabinoid (eCB) system and brain-derived neurotrophic factor (BDNF) are suggestively involved in both disorders. The findings (of this study) suggest that cannabinoids may prevent both depressive- and PTSD-like symptoms following exposure to severe stress and that alterations in BDNF levels in the brains' fear circuit are involved in these effects.

Information and Links


Link: Cannabinoids Prevent Depressive-like Symptoms And Alterations In BDNF Expression In A Rat Model Of PTSD

Year: 2018

DOI: 10.1016/j.pnpbp.2018.01.026


Ratings

(How Ratings Work)

Post-Traumatic Stress Disorder — 2


Possible to probable range of efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.

Depression — 2


Possible to probable range of efficacy of cannabis for treatment of Depression according to the results found in this study.

Drugs Used

CB1/2 receptor agonist WIN55,212-2 (0.5 mg/kg; i.p.), the fatty acid hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg, i.p.)