Post-traumatic stress disorder (PTSD) is a debilitating condition affecting the body, mind, and spirit. The condition results from direct or witnessed exposure to an extreme traumatic event such as war, police action, famine, earthquake, tsunami, assault, abuse, rape, kidnapping, torture, plane crash, explosions, life-threatening illness, or any situation involving the threat of death, extreme fear, dread, and helplessness.
PTSD most often results from sudden trauma that happens without warning, was repeated over long periods of time, included intentional violence to body and psyche and/or involved grotesque injury and death, rape, or the loss of a close friend or relative.
Rated 2.7 / 5 (How Ratings Work)
Possible to probable range of efficacy of cannabis for treatment of post-traumatic stress disorder.
Based on 19 Studies from 1996 - 2017
Study Name, Description & Year
Rating
Endocannabinoid Signalling Modulates Susceptibility To Traumatic Stress Exposure
Animal study (mice) — 2017
Endocannabinoid Concentrations In Hair Are Associated With PTSD Symptom Severity.
Human trial conducted on 38 rebel war survivors from Northern Uganda suffering from PTSD. — 2016
Effectiveness Of Cannabidiol Oil For Pediatric Anxiety And Insomnia As Part Of Posttraumatic Stress Disorder: A Case Report
Case study conducted on a pediatric patient suffering from PTSD after sexual assault. — 2016
FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence
Human trial conducted on forty-nine patients with PTSD and Alcohol Dependence. — 2016
Bidirectional Effects Of Cannabidiol On Contextual Fear Memory Extinction
Animal study (rats) — 2016
Reductions In Circulating Endocannabinoid Levels In Individuals With Post-traumatic Stress Disorder Following Exposure To The World Trade Center Attacks.
Cohort study conducted on 46 people in close proximity to the World Trade Center collapse. 24 of them were diagnosed with a lifetime diagnosis of PTSD. — 2013
Role Of The Endocannabinoid System In Extinction Of Fear Memories: Lessons From Animal Studies
Animal study (mice) — 2012
Mitigation Of Post-traumatic Stress Symptoms By Cannabis Resin: A Review Of The Clinical And Neurobiological Evidence.
Single human case study of a patient with severe PTSD symptoms. — 2012
Cannabinoid Receptor Activation In The Basolateral Amygdala Blocks The Effects Of Stress On The Conditioning And Extinction Of Inhibitory Avoidance
Animal study (rats) — 2009
The Use Of A Synthetic Cannabinoid In The Management Of Treatment-resistant Nightmares In Posttraumatic Stress Disorder (PTSD)
Human case study (47 patients diagnosed with PTSD) — 2009
5-HT1A Receptors Are Involved In The Cannabidiol-induced Attenuation Of Behavioural And Cardiovascular Responses To Acute Restraint Stress In Rats
Animal study (Wistar rats) — 2009
Differential Endocannabinoid Regulation Of Extinction In Appetitive And Aversive Barnes Maze Tasks
Animal study — 2008
Cannabinoids Augment The Release Of Neuropeptide Y In The Rat Hypothalamus
Animal study (rats) — 2005
Inhibition Of Exocytotic Noradrenaline Release By Presynaptic Cannabinoid CB1 Receptors On Peripheral Sympathetic Nerves.
Animal study (mice) — 1996