CB1 Cannabinoid Receptors Promote Oxidative/nitrosative Stress, Inflammation And Cell Death In A Murine Nephropathy Model

Kidney Disease (in General)

Key Findings

The endocannabinoid system through CB(1) receptors promotes cisplatin-induced tissue injury by amplifying MAPK activation, cell death and interrelated inflammation and oxidative/nitrosative stress. These results also suggest that inhibition of CB(1) receptors may exert beneficial effects in renal (and most likely other) diseases associated with enhanced inflammation, oxidative/nitrosative stress and cell death.

Information and Links


Link: CB1 Cannabinoid Receptors Promote Oxidative/nitrosative Stress, Inflammation And Cell Death In A Murine Nephropathy Model

Year: 2010

DOI: 10.1111/j.1476-5381.2010.00769.x


Ratings

(How Ratings Work)

Kidney Disease (in General) — 2


Possible to probable range of efficacy of cannabis for treatment of Kidney Disease (in General) according to the results found in this study.

Drugs Used

AM281 or SR141716