Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice.

Emotional and Behavioral Disorders (EBD)

Key Findings

Contrasting data were reported regarding the effects of cannabinoids on anxiety and social behaviour in both animals and humans. CB1 gene disruption promoted aggressive behaviour in the home-cage, whereas it inhibited social behaviour in the unfamiliar cage. Results suggest that the effects of CB1 gene disruption were context and not behaviour specific. The present data at least partly explain contrasting effects of cannabinoids in different contexts as well as in different species and strains that show differential stress responses and coping strategies.

Information and Links


Link: Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice.

Year: 2004


Ratings

(How Ratings Work)

Emotional and Behavioral Disorders (EBD) — 2


Possible to probable range of efficacy of cannabis for treatment of Emotional and Behavioral Disorders (EBD) according to the results found in this study.

Drugs Used

Cannabinoids