CBC and THCV suppressed sebaceous lipid synthesis, CBDV had only minor effects, whereas CBG and CBGV increased it. Importantly, CBC, CBDV and THCV significantly reduced arachidonic acid (AA)-induced "acne-like" lipogenesis. Moreover, THCV suppressed proliferation, and all phytocannabinoids exerted remarkable anti-inflammatory actions. Our data suggest that CBG and CBGV may have potential in the treatment of dry-skin syndrome, whereas CBC, CBDV and especially THCV show promise to become highly efficient, novel anti-acne agents.
Link: Differential Effectiveness Of Selected Non-psychotropic Phytocannabinoids On Human Sebocyte Functions Implicates Their Introduction In Dry/seborrheic Skin And Acne Treatment
Year: 2016
DOI: 10.1111/exd.13042