Endocannabinoids accumulate in hair and concentrations over time give access to a more stable and reliable assessment than blood samples. Compared to the healthy group patients suffering from PTSD showed a significant reduction in the endocannabinoids OEA, PEA, and SEA. The observed reductions in endocannabinoids might account for the increased inflammatory state as well as for the failure to extinguish fear memories observed in PTSD.
Likely probability of the efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.
N-acyl-ethanolamides palmitoylethanolamide [PEA], oleoylethanolamide [OEA] and stearoylethanolamide [SEA]