Endocannabinoids: A Promising Impact For Traumatic Brain Injury

Traumatic Brain Injury

Key Findings

Manipulations of endocannabinoid degradative enzymes (e.g., fatty acid amide hydrolase, monoacylglycerol lipase, and α/β-hydrolase domain-6), CB1 and CB2 receptors, and their endogenous ligands have shown promise in modulating cellular and molecular hallmarks of TBI pathology such as; cell death, excitotoxicity, neuroinflammation, cerebrovascular breakdown, and cell structure and remodeling. TBI-induced behavioral deficits, such as learning and memory, neurological motor impairments, post-traumatic convulsions or seizures, and anxiety also respond to manipulations of the endocannabinoid system.

Information and Links


Link: Endocannabinoids: A Promising Impact For Traumatic Brain Injury

Year: 2017

DOI: 10.3389/fphar.2017.00069


Ratings

(How Ratings Work)

Traumatic Brain Injury — 3


Likely probability of the efficacy of cannabis for treatment of Traumatic Brain Injury according to the results found in this study.

Drugs Used

ECS review

Synthetic cannabinoid CT-3, a potent analog of THC-11-oic acid