Endocannabinoids Affect Innate Immunity Of Muller Glia During HIV-1 Tat Cytotoxicity

Uveitis HIV/AIDS Retinal Disease

Key Findings

Individuals with HIV-1 often sufferfrom visual impairment and opportunistic retinitis. Endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol are used to alleviate Tat-induced cytotoxicity and rescue retinal cells. These findings have direct relevance in conditions like immune-recovery uveitis where anti-retroviral therapy has helped immune reconstitution. Endocannabinoids and their agonists may be thought of as neurotherapeutic during certain conditions of HIV-1 induced inflammation. We suggest that exogenous application of endocannabinoids and their agonists can also function in inflammatory diseases of the eye, even those induced by HIV infection.

Information and Links


Link: Endocannabinoids Affect Innate Immunity Of Muller Glia During HIV-1 Tat Cytotoxicity

Year: 2014

DOI: 10.1016/j.mcn.2014.01.001


Ratings

(How Ratings Work)

Uveitis — 1


Possibility of efficacy for cannabis in treatment of Uveitis according to the results found in this study.

HIV/AIDS — 1


Possibility of efficacy for cannabis in treatment of HIV/AIDS according to the results found in this study.

Retinal Disease — 1


Possibility of efficacy for cannabis in treatment of Retinal Disease according to the results found in this study.

Drugs Used

N-arachidonoylethanolamide and 2-arachidonoylglycerol