Endocannabinoids Enhance Lipid Synthesis And Apoptosis Of Human Sebocytes Via Cannabinoid Receptor-2-mediated Signaling

Acne Seborrhea

Key Findings

Sebocytes express CB2 but not CB1. Also, anandamide and 2-AG are present in SZ95 sebocytes and dose-dependently induce lipid production and (chiefly apoptosis-driven) cell death. Endocannabinoids also up-regulate the expression of key genes involved in lipid synthesis. CB2 antagonists or agonists therefore deserve to be explored in the management of skin disorders characterized by sebaceous gland dysfunctions (e.g., acne vulgaris, seborrhea, dry skin).

Information and Links


Link: Endocannabinoids Enhance Lipid Synthesis And Apoptosis Of Human Sebocytes Via Cannabinoid Receptor-2-mediated Signaling

Year: 2008

DOI: 10.1096/fj.07-104877


Ratings

(How Ratings Work)

Acne — 1


Possibility of efficacy for cannabis in treatment of Acne according to the results found in this study.

Seborrhea — 1


Possibility of efficacy for cannabis in treatment of Seborrhea according to the results found in this study.

Drugs Used

Anandamide (AEA)

2-AG