FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Post-Traumatic Stress Disorder Stress Alcohol Dependence / Abuse

Key Findings

A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress responses in healthy volunteers. Here, we obtained genotypes and carried out a secondary analysis of subjects from a trial of comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). This is to our knowledge the first study showing that FAAH C385A variation modulates stress responses in subjects with disorders characterized by increased stress reactivity. These findings point to the eCB pathway as a promising target for future antistress therapeutics.

Information and Links


Link: FAAH Gene Variation Moderates Stress Response And Symptom Severity In Patients With Posttraumatic Stress Disorder And Comorbid Alcohol Dependence

Year: 2016

DOI: 10.1111/acer.13210


Ratings

(How Ratings Work)

Post-Traumatic Stress Disorder — 4


Probability toward demonstrable efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.

Stress — 4


Probability toward demonstrable efficacy of cannabis for treatment of Stress according to the results found in this study.

Alcohol Dependence / Abuse — 4


Probability toward demonstrable efficacy of cannabis for treatment of Alcohol Dependence / Abuse according to the results found in this study.

Drugs Used

FAAH Gene