Impact Of Co-administration Of Oxycodone And Smoked Cannabis On Analgesia And Abuse Liability

Addiction to Opiod Based Pain Killers Addiction to Heroin Pain (nociceptive)

Key Findings

Cannabis enhances the analgesic effects of sub-threshold oxycodone, suggesting synergy, without increases in cannabis's abuse liability. These findings support future research into the therapeutic use of opioid-cannabinoid combinations for pain.

Information and Links


Link: Impact Of Co-administration Of Oxycodone And Smoked Cannabis On Analgesia And Abuse Liability

Year: 2018

DOI: 10.1038/s41386-018-0011-2


Ratings

(How Ratings Work)

Addiction to Opiod Based Pain Killers — 5


Demonstrable efficacy of cannabis for treatment of Addiction to Opiod Based Pain Killers according to the results found in this study.

Addiction to Heroin — 5


Demonstrable efficacy of cannabis for treatment of Addiction to Heroin according to the results found in this study.

Pain (nociceptive) — 5


Demonstrable efficacy of cannabis for treatment of Pain (nociceptive) according to the results found in this study.

Drugs Used

Oxycodone (0, 2.5, and 5.0 mg, PO) with smoked cannabis (0.0, 5.6% Δ9 tetrahydrocannabinol)