Inhibition Of Fatty Acid Amide Hydrolase Reduces Reinstatement Of Nicotine Seeking But Not Break Point For Nicotine Self-administration--comparison With CB(1) Receptor Blockade

Addiction to Nicotine

Key Findings

Results indicate that the integrity of the CB(1) receptors is necessary for the incentive motivation of the rats for nicotine and that FAAH inhibition may be as effective as CB(1) receptor blockade to prevent reinstatement of nicotine seeking. Since FAAH inhibition present antidepressant and anxiolytic properties in rodents, targeting the FAAH may represent a novel strategy to prevent relapse for tobacco smoking that may be better tolerated than rimonabant.

Information and Links


Link: Inhibition Of Fatty Acid Amide Hydrolase Reduces Reinstatement Of Nicotine Seeking But Not Break Point For Nicotine Self-administration--comparison With CB(1) Receptor Blockade

Year: 2009

DOI: 10.1007/s00213-009-1569-5


Ratings

(How Ratings Work)

Addiction to Nicotine — 2


Possible to probable range of efficacy of cannabis for treatment of Addiction to Nicotine according to the results found in this study.

Drugs Used

URB597

Rimonabant