Inhibition Of Guinea-pig And Human Sensory Nerve Activity And The Cough Reflex In Guinea-pigs By Cannabinoid (CB2) Receptor Activation

Cough

Key Findings

These data show that activation of the CB2 receptor subtype inhibits sensory nerve activation of guinea-pig and human vagus nerve, and the cough reflex in guinea-pigs, suggesting that the development of CB2 agonists, devoid of CB1-mediated central effects, will provide a new and safe antitussive treatment for chronic cough.

Information and Links


Link: Inhibition Of Guinea-pig And Human Sensory Nerve Activity And The Cough Reflex In Guinea-pigs By Cannabinoid (CB2) Receptor Activation

Year: 2003

DOI: 10.1038/sj.bjp.0705435


Ratings

(How Ratings Work)

Cough — 2


Possible to probable range of efficacy of cannabis for treatment of Cough according to the results found in this study.

Drugs Used

CP 55940

JWH 133

SR144528

SR141716A