Involvement Of Peripheral Cannabinoid And Opioid Receptors In β-caryophyllene-induced Antinociception

Pain (Acute)

Key Findings

The present results demonstrate that antinociception produced by i.pl. BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid β-endorphin. The combined injection of morphine and BCP may be an alternative in treating chemogenic pain.

Information and Links


Link: Involvement Of Peripheral Cannabinoid And Opioid Receptors In β-caryophyllene-induced Antinociception

Year: 2013

DOI: 10.1002/j.1532-2149.2012.00242.x


Ratings

(How Ratings Work)

Pain (Acute) — 2


Possible to probable range of efficacy of cannabis for treatment of Pain (Acute) according to the results found in this study.

Drugs Used

β-Caryophyllene

AM630

AM251