Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids.

Stress Emotional and Behavioral Disorders (EBD)

Key Findings

Genetic and pharmacological studies demonstrate that the reduction in anandamide signaling may be involved in the initiation of HPA axis activation and the generation of changes in emotional behaviour, while the increase in 2-AG signaling may be involved in terminating the stress response, limiting neuronal activation and contributing to changes in motivated behaviors.

Information and Links


Link: Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids.

Year: 2010

DOI: 10.1016/j.pnpbp.2009.11.001


Ratings

(How Ratings Work)

Stress — 3


Likely probability of the efficacy of cannabis for treatment of Stress according to the results found in this study.

Emotional and Behavioral Disorders (EBD) — 3


Likely probability of the efficacy of cannabis for treatment of Emotional and Behavioral Disorders (EBD) according to the results found in this study.

Drugs Used

Endocannabinoids