Ligand activation of cannabinoid receptors attenuates hypertrophy of neonatal rat cardiomyocytes.

Heart Disease

Key Findings

Evidence suggests that activation of the endocannabinoid pathway offers cardioprotection against myocardial ischemia, arrhythmias, and endothelial dysfunction of coronary arteries. Ligand activation of cannabinoid receptors attenuates hypertrophy of neonatal rat cardiomyocytes. In conclusion, CB-13 inhibits cardiomyocyte hypertrophy through AMPK-eNOS signaling and may represent a novel therapeutic approach to cardioprotection.

Information and Links


Link: Ligand activation of cannabinoid receptors attenuates hypertrophy of neonatal rat cardiomyocytes.

Year: 2014

DOI: 10.1097/FJC.0000000000000134


Ratings

(How Ratings Work)

Heart Disease — 1


Possibility of efficacy for cannabis in treatment of Heart Disease according to the results found in this study.

Drugs Used

CB-13

JWH-133

Anandamide

R-methanandamide