Opioid-Sparing Effect Of Cannabinoids: A Systematic Review And Meta-Analysis

Pain (Acute) Pain (Chronic Non-Malignant) Intervertebral Disc Degeneration (chronic lower back pain)

Key Findings

Our meta-analysis of pre-clinical studies indicated that the median effective dose (ED50) of morphine administered in combination with delta-9-tetrahydrocannabinol (delta-9-THC) is 3.6 times lower (95% confidence interval (CI) 1.95, 6.76; n=6) than the ED50 of morphine alone. In addition, the ED50 for codeine administered in combination with delta-9-THC was 9.5 times lower (95% CI 1.6, 57.5, n=2) than the ED50 of codeine alone. In summary, pre-clinical studies provide robust evidence of the opioid-sparing effect of cannabinoids.

Information and Links


Link: Opioid-Sparing Effect Of Cannabinoids: A Systematic Review And Meta-Analysis

Year: 2017

DOI: 10.1038/npp.2017.51


Ratings

(How Ratings Work)

Pain (Acute) — 3


Likely probability of the efficacy of cannabis for treatment of Pain (Acute) according to the results found in this study.

Pain (Chronic Non-Malignant) — 3


Likely probability of the efficacy of cannabis for treatment of Pain (Chronic Non-Malignant) according to the results found in this study.

Intervertebral Disc Degeneration (chronic lower back pain) — 3


Likely probability of the efficacy of cannabis for treatment of Intervertebral Disc Degeneration (chronic lower back pain) according to the results found in this study.

Drugs Used

THC