Our meta-analysis of pre-clinical studies indicated that the median effective dose (ED50) of morphine administered in combination with delta-9-tetrahydrocannabinol (delta-9-THC) is 3.6 times lower (95% confidence interval (CI) 1.95, 6.76; n=6) than the ED50 of morphine alone. In addition, the ED50 for codeine administered in combination with delta-9-THC was 9.5 times lower (95% CI 1.6, 57.5, n=2) than the ED50 of codeine alone. In summary, pre-clinical studies provide robust evidence of the opioid-sparing effect of cannabinoids.
Link: Opioid-Sparing Effect Of Cannabinoids: A Systematic Review And Meta-Analysis
Year: 2017
DOI: 10.1038/npp.2017.51
Likely probability of the efficacy of cannabis for treatment of Pain (Acute) according to the results found in this study.
Likely probability of the efficacy of cannabis for treatment of Pain (Chronic Non-Malignant) according to the results found in this study.
Likely probability of the efficacy of cannabis for treatment of Intervertebral Disc Degeneration (chronic lower back pain) according to the results found in this study.
THC