Potentiating Effect Of Beta-caryophyllene On Anticancer Activity Of Alpha-humulene, Isocaryophyllene And Paclitaxel

Cancer (Breast) Cancer (Colon)

Key Findings

Tested on MCF-7 (breast cancer cells) and DLD-1 (colon cancer cells). Study results suggest that beta-caryophyllene facilitates the passage of paclitaxel through the membrane and thus potentiates its anticancer activity. The highest potentiating effect was obtained in DLD-1 cells treated with paclitaxel combined with 10 microg mL(-1) beta-caryophyllene, which increased the paclitaxel activity about 10-fold.

Information and Links


Link: Potentiating Effect Of Beta-caryophyllene On Anticancer Activity Of Alpha-humulene, Isocaryophyllene And Paclitaxel

Year: 2007

DOI: 10.1211/jpp.59.12.0005


Ratings

(How Ratings Work)

Cancer (Breast) — 1


Possibility of efficacy for cannabis in treatment of Cancer (Breast) according to the results found in this study.

Cancer (Colon) — 1


Possibility of efficacy for cannabis in treatment of Cancer (Colon) according to the results found in this study.

Drugs Used

Beta-caryophyllene

Alpha-humulene

Isocaryophyllene

Paclitaxel