Promising Cannabinoid-based Therapies For Parkinson’s Disease: Motor Symptoms To Neuroprotection

Parkinson's Disease

Key Findings

The elements of the endocannabinoid system are highly expressed in the neural circuit of basal ganglia wherein they bidirectionally interact with dopaminergic, glutamatergic, and GABAergic signaling systems. Cannabinoids have been demonstrated experimentally as neuroprotective agents in PD, with respect to their ability to suppress excitotoxicity, glial activation, and oxidative injury that causes degeneration of dopaminergic neurons. Additional benefits provided by cannabinoid related compounds have been reported to possess efficacy against bradykinesia and levodopa-induced dyskinesia in PD.

Information and Links


Link: Promising Cannabinoid-based Therapies For Parkinson’s Disease: Motor Symptoms To Neuroprotection

Year: 2015

DOI: 10.1186/s13024-015-0012-0


Ratings

(How Ratings Work)

Parkinson's Disease — 3


Likely probability of the efficacy of cannabis for treatment of Parkinson's Disease according to the results found in this study.

Drugs Used

Cannabinoids