Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.

Stress Depression

Key Findings

Endocannabinoid content in limbic structures which regulate activation of the hypothalamic-pituitary-adrenal (HPA) axis is dynamically regulated by stress. Under conditions of acute stress, the endocannabinoid system tonically constrains activation of the HPA axis. During repeated exposure to aversive stimuli, the endocannabinoid system up-regulates in limbic structures, resulting in dampened neural activity in stress circuits, which could contribute to stress habituation. Disrupted endocannabinoid signaling, on the other hand, is associated with an inability to adapt to chronic stress. Therapeutically, these data suggest that the endocannabinoid system could be dysregulated in affective disorders, such as depression, which are characterized by maladaptive stress coping.

Information and Links


Link: Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.

Year: 2008

DOI: 10.1016/j.neubiorev.2008.03.004


Ratings

(How Ratings Work)

Stress — 3


Likely probability of the efficacy of cannabis for treatment of Stress according to the results found in this study.

Depression — 3


Likely probability of the efficacy of cannabis for treatment of Depression according to the results found in this study.

Drugs Used

Endocannabinoids