Role of the endocannabinoid system in extinction of fear memories: lessons from animal studies

Stress Post-Traumatic Stress Disorder

Key Findings

Endocannabinoids play an essential role in acute fear relief. These effects are mediated via CB1 on glutamatergic nerve terminals. Signaling via CB1 on dopamine D1 receptor positive neurons contributes not only to acute fear relief but also to safety learning. Drugs promoting endocannabinoid signaling via CB1 receptors may represent a new class of compounds that combine the advantages of “happy pills” (in terms of fear and stress relief) with those of “smart drugs” (i.e., facilitated safety learning), thus increasing compliance rates and success of exposure-based therapies in anxiety disorders.

Information and Links


Link: Role of the endocannabinoid system in extinction of fear memories: lessons from animal studies

Year: 2012

DOI: http://dx.doi.org/10.3402/ejpt.v3i0.19589


Ratings

(How Ratings Work)

Stress — 2


Possible to probable range of efficacy of cannabis for treatment of Stress according to the results found in this study.

Post-Traumatic Stress Disorder — 2


Possible to probable range of efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.

Drugs Used

SR141716

AM404