Spontaneous Cannabinoid Receptor 2 (CB2) Expression In The Cochlea Of Adult Albino Rat And Its Up-Regulation After Cisplatin Treatment

Cisplatin-Induced Hearing Loss

Key Findings

An up-regulation of CB2 gene expression was detected after an ototoxic event such as cisplatin treatment, probably due to pro-inflammatory events triggered by the drug. That fact suggests promising potential of CB2 receptor as a therapeutic target for new treatments to palliate cisplatin-induced hearing loss and other ototoxic events which triggers inflammatory pathways.

Information and Links


Link: Spontaneous Cannabinoid Receptor 2 (CB2) Expression In The Cochlea Of Adult Albino Rat And Its Up-Regulation After Cisplatin Treatment

Year: 2016

DOI: 10.1371/journal.pone.0161954


Ratings

(How Ratings Work)

Cisplatin-Induced Hearing Loss — 2


Possible to probable range of efficacy of cannabis for treatment of Cisplatin-Induced Hearing Loss according to the results found in this study.

Drugs Used

CB2 receptors