Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi

Chagas Disease (Trypanosoma cruzi) Helminthiasis

Key Findings

This is the first report on the trypanocidal activity of a mixture of lupenone and caryophyllene oxide against T. cruzi in vitro and in vivo. Our results showed that the 1 : 4 mixture of lupenone and caryophyllene oxide is active in the chronic phase of the disease, reducing significantly the number of amastigote nests in both cardiac tissue and skeletal muscle.

Information and Links


Link: Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi

Year: 2013

DOI: 10.1155/2013/435398


Ratings

(How Ratings Work)

Chagas Disease (Trypanosoma cruzi) — 2


Possible to probable range of efficacy of cannabis for treatment of Chagas Disease (Trypanosoma cruzi) according to the results found in this study.

Helminthiasis — 2


Possible to probable range of efficacy of cannabis for treatment of Helminthiasis according to the results found in this study.

Drugs Used

Lupenone and Caryophyllene Oxide