Systemic And Spinal Administration Of FAAH, MAGL Inhibitors And Dual FAAH/MAGL Inhibitors Produce Antipruritic Effect In Mice

Itching (Pruritis)

Key Findings

Our results suggest that endocannabinoid-degrading enzymes FAAH and MAGL are involved in pruritic process at spinal level. FAAH, MAGL or dual FAAH/MAGL inhibitors have promising antipruritic effects, at least, in part through spinal site of action.

Information and Links


Link: Systemic And Spinal Administration Of FAAH, MAGL Inhibitors And Dual FAAH/MAGL Inhibitors Produce Antipruritic Effect In Mice

Year: 2016

DOI: 10.1007/s00403-016-1649-4


Ratings

(How Ratings Work)

Itching (Pruritis) — 2


Possible to probable range of efficacy of cannabis for treatment of Itching (Pruritis) according to the results found in this study.

Drugs Used

Fatty acid amide hydrolase (FAAH)

Monoacylglycerol lipase (MAGL)

Dual FAAH/MAGL inhibitors