Targeting Cannabinoid Signaling In The Immune System: “High”-ly Exciting Questions, Possibilities, And Challenges

Malaria Chagas Disease (Trypanosoma cruzi) HIV/AIDS Diabetes Mellitus Rheumatoid Arthritis

Key Findings

Research efforts of the past few decades have unambiguously evidenced that ECS is one of the central orchestrators of both innate and adaptive immune systems, and that pure pCBs as well as complex cannabis-derivatives can also deeply influence immune responses. Although, many open questions await to be answered, pharmacological modulation of the (endo)cannabinoid signaling, and restoration of the homeostatic eCB tone of the tissues augur to be very promising future directions in the management of several pathological inflammation-accompanied diseases. Moreover, in depth analysis of the (quite complex) mechanism-of-action of the most promising pCBs is likely to shed light to previously unknown immune regulatory mechanisms and can therefore pave new “high”-ways toward developing completely novel classes of therapeutic agents to manage a wide-variety of diseases.

Information and Links


Link: Targeting Cannabinoid Signaling In The Immune System: “High”-ly Exciting Questions, Possibilities, And Challenges

Year: 2017

DOI: https://doi.org/10.3389/fimmu.2017.01487


Ratings

(How Ratings Work)

Malaria — 3


Likely probability of the efficacy of cannabis for treatment of Malaria according to the results found in this study.

Chagas Disease (Trypanosoma cruzi) — 3


Likely probability of the efficacy of cannabis for treatment of Chagas Disease (Trypanosoma cruzi) according to the results found in this study.

HIV/AIDS — 3


Likely probability of the efficacy of cannabis for treatment of HIV/AIDS according to the results found in this study.

Diabetes Mellitus — 3


Likely probability of the efficacy of cannabis for treatment of Diabetes Mellitus according to the results found in this study.

Rheumatoid Arthritis — 3


Likely probability of the efficacy of cannabis for treatment of Rheumatoid Arthritis according to the results found in this study.

Drugs Used

Endocannabinoids

Cannabinoids

Synthetic cannabinoids