The Cannabinoid Receptor 2 Is Involved In Acute Rejection Of Cardiac Allografts

Organ Transplant, Graft Rejection

Key Findings

Acute rejection of cardiac allografts is a major risk factor limiting survival of heart transplant recipients. The cannabinoid receptor 2 (CB2) is an important modulator of cellular immune responses. The findings and the fact that allograft rejection is enhanced in Cnr2(-/-) mice suggest that CB2 may be a promising therapeutic target in organ transplantation.

Information and Links


Link: The Cannabinoid Receptor 2 Is Involved In Acute Rejection Of Cardiac Allografts

Year: 2015

DOI: 10.1016/j.lfs.2015.02.012


Ratings

(How Ratings Work)

Organ Transplant, Graft Rejection — 2


Possible to probable range of efficacy of cannabis for treatment of Organ Transplant, Graft Rejection according to the results found in this study.

Drugs Used

CB2 receptor sites and their interaction with pro-inflammatory cytokines.