The Cannabinoids Δ8THC, CBD, And HU-308 Act Via Distinct Receptors To Reduce Corneal Pain And Inflammation

Pain (Eye)

Key Findings

Topical cannabinoids reduce corneal hyperalgesia and inflammation. The antinociceptive and anti-inflammatory effects of Δ8THC are mediated primarily via CB1R, whereas that of the cannabinoids CBD and HU-308, involve activation of 5-HT1A receptors and CB2Rs, respectively. Cannabinoids could be a novel clinical therapy for corneal pain and inflammation resulting from ocular surface injury.

Information and Links


Link: The Cannabinoids Δ8THC, CBD, And HU-308 Act Via Distinct Receptors To Reduce Corneal Pain And Inflammation

Year: 2018

DOI: 10.1089/can.2017.0041


Ratings

(How Ratings Work)

Pain (Eye) — 2


Possible to probable range of efficacy of cannabis for treatment of Pain (Eye) according to the results found in this study.

Drugs Used

Δ8-tetrahydrocannabinol (Δ8THC) or cannabidiol (CBD), or the CBD derivative HU-308

AM251

5-HT1A receptor antagonist WAY100635