The Endocannabinoid System As A Possible Target To Treat Both The Cognitive And Emotional Features Of Post-traumatic Stress Disorder (PTSD)

Post-Traumatic Stress Disorder

Key Findings

Due to the wide expression of cannabinoid receptors throughout limbic regions of the brain, endocannabinoids control both emotional behavior and cognitive processes. Endocannabinoids have an essential role in maintaining emotional homeostasis. Endocannabinoids regulate affective states and participate in memory consolidation, retrieval, and extinction. Clinical findings showing a relationship between Cannabis use and PTSD, as well as changes in endocannabinoid activity in PTSD patients, further suggest the existence of a link between endocannabinoids and maladaptive brain changes after trauma exposure. Along these lines, we suggest that endocannabinoid degradation inhibitors may be an ideal therapeutic approach to simultaneously treat the emotional and cognitive features of PTSD, avoiding the unwanted psychotropic effects of compounds directly binding cannabinoid receptors.

Information and Links


Link: The Endocannabinoid System As A Possible Target To Treat Both The Cognitive And Emotional Features Of Post-traumatic Stress Disorder (PTSD)

Year: 2013

DOI: 10.3389/fnbeh.2013.00100


Ratings

(How Ratings Work)

Post-Traumatic Stress Disorder — 3


Likely probability of the efficacy of cannabis for treatment of Post-Traumatic Stress Disorder according to the results found in this study.

Drugs Used

Cannabinoids

Endocannabinoid degradation inhibitors