The Influence Of Cannabinoids On Generic Traits Of Neurodegeneration

Parkinson's Disease Alzheimer's Disease Huntington's Disease

Key Findings

Modulation of the endogenous cannabinoid system is emerging as a potentially viable option in the treatment of neurodegeneration. Signalling from the CB1 and CB2 receptors are known to be involved in the regulation of Ca(2+) homeostasis, mitochondrial function, trophic support and inflammatory status, respectively, while other receptors gated by cannabinoids such as PPARγ, are gaining interest in their anti-inflammatory properties. Through multiple lines of evidence, this evolutionarily conserved neurosignalling system has shown neuroprotective capabilities and is therefore a potential target for neurodegenerative disorders.

Information and Links


Link: The Influence Of Cannabinoids On Generic Traits Of Neurodegeneration

Year: 2014

DOI: 10.1111/bph.12492


Ratings

(How Ratings Work)

Parkinson's Disease — 3


Likely probability of the efficacy of cannabis for treatment of Parkinson's Disease according to the results found in this study.

Alzheimer's Disease — 3


Likely probability of the efficacy of cannabis for treatment of Alzheimer's Disease according to the results found in this study.

Huntington's Disease — 3


Likely probability of the efficacy of cannabis for treatment of Huntington's Disease according to the results found in this study.

Drugs Used

Cannabinoids