Modulation of the endogenous cannabinoid system is emerging as a potentially viable option in the treatment of neurodegeneration. Signalling from the CB1 and CB2 receptors are known to be involved in the regulation of Ca(2+) homeostasis, mitochondrial function, trophic support and inflammatory status, respectively, while other receptors gated by cannabinoids such as PPARγ, are gaining interest in their anti-inflammatory properties. Through multiple lines of evidence, this evolutionarily conserved neurosignalling system has shown neuroprotective capabilities and is therefore a potential target for neurodegenerative disorders.
Link: The Influence Of Cannabinoids On Generic Traits Of Neurodegeneration
Year: 2014
DOI: 10.1111/bph.12492
Likely probability of the efficacy of cannabis for treatment of Parkinson's Disease according to the results found in this study.
Likely probability of the efficacy of cannabis for treatment of Alzheimer's Disease according to the results found in this study.
Likely probability of the efficacy of cannabis for treatment of Huntington's Disease according to the results found in this study.
Cannabinoids