TRP Channel Cannabinoid Receptors In Skin Sensation, Homeostasis, And Inflammation

Acne Itching (Pruritis)

Key Findings

The skin possesses a robust capacity to synthesize and respond to cannabinoids. In human skin, CB1 is expressed in keratinocytes within the more differentiated epidermal layers, hair follicle cells, sebaceous glands, sensory neurons, and immune cells. CB2 is expressed in keratinocytes, sebaceous glands, sensory neurons, and immune cells. The functional effects of cannabinoids on skin can be divided into four general categories: (1) Regulation of epidermal homeostasis. (2) Regulation of pain sensation. (3) Regulation of skin inflammation. (4) Regulation of skin appendages. Cannabinoids can engage numerous targets within the skin, including not only metabotropic receptors, but also multiple members of the TRP family of ion channels. Cutaneous ionotropic cannabinoid receptors participate in functions related to pain and itch perception, epidermal homeostasis, and the promotion and suppression of dermatitis in both animal models and humans. This situation creates potential opportunities to intervene therapeutically in sensory and inflammatory skin diseases using the chemically rich pharmacology of cannabinoids.

Information and Links


Link: TRP Channel Cannabinoid Receptors In Skin Sensation, Homeostasis, And Inflammation

Year: 2014

DOI: 10.1021/cn5000919


Ratings

(How Ratings Work)

Acne — 3


Likely probability of the efficacy of cannabis for treatment of Acne according to the results found in this study.

Itching (Pruritis) — 3


Likely probability of the efficacy of cannabis for treatment of Itching (Pruritis) according to the results found in this study.

Drugs Used

Endocannabinoids

Cannabinoids