Variants In The CNR1 Gene Predispose To Headache With Nausea In The Presence Of Life Stress

Stress Migraine

Key Findings

One of the main effects of the endocannabinoid system in the brain is stress adaptation with presynaptic endocannabinoid receptor 1 (CB1 receptors) playing a major role. In summary, the CNR1 gene in interaction with life stress increased the risk of headache with nausea suggesting a specific pathological mechanism to develop migraine, and indicating that a subgroup of migraine patients, who suffer from life stress triggered migraine with frequent nausea, may benefit from therapies that increase the endocannabinoid tone.

Information and Links


Link: Variants In The CNR1 Gene Predispose To Headache With Nausea In The Presence Of Life Stress

Year: 2016

DOI: 10.1111/gbb.12352


Ratings

(How Ratings Work)

Stress — 4


Probability toward demonstrable efficacy of cannabis for treatment of Stress according to the results found in this study.

Migraine — 4


Probability toward demonstrable efficacy of cannabis for treatment of Migraine according to the results found in this study.

Drugs Used

CB1 receptor coding CNR1 gene