Tag: research (page 3 of 16)

Scientists Successfully Crystalize and Reveal the Structure of our CB1 Receptor

For the first time, we can visualize how cannabinoids fit like puzzle pieces, into the CB1 cannabinoid receptors in our brains.

This exciting news was reveled in a paper published in Cell and openly available titled: “Crystal Structure of the Human Cannabinoid Receptor CB1.”

From the paper itself:

“In combination with functional studies and molecular modeling, the structure provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids. This enhances our understanding of the molecular basis for the physiological functions of CB1 and provides new opportunities for the design of next-generation CB1-targeting pharmaceuticals.”

There are at least 113 known cannabinoids. Some of them are produced in our own brains like anandamide. While others like THC, are produced in plants. The CB1 and CB2 receptors in our bodies are responsible for regulating a whole host of things like pain, mood, appetite, and more. Being able to further understand how they work and interact with various cannabinoids will pave the way for novel and new treatments that interact with those receptors.

Docking Pose of THC on the CB1 Receptor

Docking Pose of THC on the CB1 Receptor

Researching new ways to interact with the CB1 receptor is exciting, but revealing the mechanisms more thoroughly are also helpful for a current public safety problem of synthetic cannabinoids. We still don’t understand why some synthetic cannabinoids like JWH-018 can cause extremely violent, dangerous, and sometimes deadly results while others like THC are quite safe with no overdoses recorded.

Overall Structure of CB1

Overall Structure of CB1

Cannabinoid receptors are part of a class of receptors in our brain known as G protein-coupled receptors (CPCR). The CB1 and CB2 receptors are the most abundant of these receptors in the human body. Most of the best-selling drugs on the market target GPCR and estimates of 40-50% of all pharmaceuticals target them as well. Increasing our understanding of this most abundant and important receptor in our brains is an exciting field with more benefits clearly on the horizon.

You can access the paper free of charge from Cell via their website, or here’s a direct link to the PDF.

Crystal Structure of the Human Cannabinoid Receptor CB1

Crystal Structure of the Human Cannabinoid Receptor CB1 PDF

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Baltimore Ravens Prepare to Dump Eugene Monroe and His Pro-Cannabis Efforts

The NFL just cannot seem to win when it comes to cannabis. National organizations are typically stubborn when it comes to shifting attitudes toward medical cannabis, but the NFL is notoriously overreaching when it comes to punishing players who use cannabis.


Reports surfaced this week that the Baltimore Ravens are trying to trade offensive tackle Eugene Monroe, who earlier this year publicly donated thousands of dollars to cannabis research. Monroe took a lot of heat for his opinions, but the American public responded positively.


Opioid addiction and traumatic brain injuries have plagued this sport known for its violent hits and extreme physical impacts.


The Ravens organization never supported Monroe’s attitudes toward cannabis research, with head coach John Harbaugh reportedly saying, “I promise you, [Monroe] does not speak for the organization.”

The Baltimore Ravens began making attempts to trade Monroe early this week, and reports indicate that if they cannot find a new team for him by Thursday, they will cut him.

There are very few legitimate player protections in the NFL, and none of them would ever cover someone advocating cannabis.


Baltimore is adamant that the decision to move away from Monroe is totally football-related, pointing to the recent draft of Ronnie Stanley and Monroe’s history of injuries.

However, critics of the Ravens decision have pointed to the fact that Monroe’s injuries have been a known factor for quite some time, and that Ronnie Stanley was drafted nearly two months ago.

Teams often make quick personnel decisions, but when it comes to the NFL’s first active player to publicly advocate for cannabis, many people believe there is much more going on here.


Some have even suggested that Roger Goodell, Commissioner of the NFL, has been applying pressure internally to guarantee that Monroe is not picked up by another football organization.

Goodell has been making headlines lately for his mishandling of several high-profile punishments, including a months-long incident with star quarterback Tom Brady.

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Another Week in the World of Cannabis: June 3rd, 2016

Cannabis is emerging from the shadows of prohibition. Every week, there are advancements in many fields related to cannabis. Cannabis Reports will be re-capping the weekly events of the cannabis community and industry, so that you can stay up-to-date on the latest developments.

Oregon Launches Recreational Access to Edibles and Concentrates

Oregon voters legalized recreational cannabis back in 2014, and the roll-out of the recreational program has been a little bit bumpy.


While things are not perfect, as of June 2nd, 2016, recreational cannabis consumers are now allowed to purchase edibles, topicals, and concentrates from dispensaries.


There are limits in place for recreational consumers, and dispensaries are only allowed to sell a single low-dose cannabinoid edible with 15 mg of THC or less, a single pre-filled concentrate receptacle, and topicals with no more than 6% THC.

Canadian Cannabis Officials to Speak at FDA Conferene This Month

The Food and Drug Administration is finally taking cannabis seriously. After having sent the Drug Enforcement Agency a recommendation in September of 2015, the FDA will now host officials in charge of Canada’s medical cannabis program.


At a conference slated for later this month, Canadian government officials will conduct a panel examining the legal system in place there.


Reports have suggested that not only is the DEA completely re-examining their stance on cannabis scheduling, but they plan on making a decision on the matter in the very near future.

Possible Landmark 280E Cannabis Business Case

Bay Area attorney Henry Wykowski is fighting hard for cannabis businesses. Last month, the Department of Justice dropped a long-standing case against Wykowski’s client Harborside Health Center.


Next Monday, Wykowski will begin a new trial on behalf of Harborside, this time with the U.S. Tax Court over Internal Revenue Code 280E.

IRC 280E is a major burden on cannabis businesses, and currently keeps the majority of businesses in the red operationally.


Wykowski intends to argue that 280E was never intended to govern businesses operating compliantly under their state’s laws.

The trial should take about a week, although the judge’s decision may not be released until late this year or early next year, according to Wykowski.

Ohio Group Stops Campaign Due to House Bill 523

Ohioans for Medical Marijuna have abandoned their campaign to put a medical cannabis bill in front of voters this November.


Ohioans for Medical Marijuana, backed by national group Marijuana Policy Project (MPP), has stated that they are no longer fighting for the Ohio ballot measure that would have allowed patients to grow and consume their own cannabis plants.


Many supporters are upset that the group has given in so quietly, but House Bill 523, the state legislature’s medical cannabis law, has already passed both houses and is on Governor John Katich’s desk right now. He is expected to sign House Bill 523 in the coming days.

Chronic Cannabis Use May Cause Periodontal Issues

Assistant Professor Madeline H. Meier of Arizona State University, along with fellow researchers, reviewed the findings from the New Zealand study.


The study followed the cannabis habits of 1,037 New Zealanders, and found that cannabis caused no substantial medical issues beyond moderate periodontal health decline.

Enthusiasts Gather For Mass Pot-Smoking Celebration

Meier’s team has used data from this study in the past, including an instance in which he team concluded that cannabis may cause a decline in IQ after persistent use. However, researchers conducting follow-up studies found no evidence of this cognitive decline.

Upcoming Cannabis Events

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Las Vegas Hemp Fest – (Las Vegas, NV: June 4)

Las Vegas Hemp Fest is the #1 leading Marijuana Business seminars & music festival. This is an annual two-day event, held the first weekend of June each year at AMP, the Las Vegas Amphitheater and events park located on Craig Road just up from the Cannery Casino Hotel.

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The Secret Cup – (Portland, ME: June 4-5)

Over 40 hash makers can compete with their best concentrates, from all over the world, to see if they have what it takes to win the golden torch and take the next step to win the belt, in the most legitimate cannabis competition around.


Potluck’s Fantastic Cannabastic – (San Diego, CA: June 5)

Alternative wellness industry professionals, educators, manufacturers, collectives, caregivers, patients, entertainers and more will be at this fantastic event. All California Cannabis patients ages 18+ are encouraged to attend to continue educating themselves about alternative medicines as well as contribute to the operation of their respective collectives. Enjoy a variety of fantastic live music indoors while mingling with our various enlightening event participants.


Cottonmouth Comedy Tour – (Maryland Heights, MO: June 6)

CottonMouth Comedy Tour is rolling it up, and down the west coast bringing you a stage show unlike any other of course with a medicated twist. Come check out some local vendors from the MMJ and recreational cannabis businesses in your local area. Enjoy a full stand up comedy show featuring some of the top up and coming “pot comics” in the WORLD.


Viridian Cannabis Investment Series – (Fort Lauderdale, FL: June 8)

Viridian Capital Advisors, a financial and strategic advisory firm dedicated to the cannabis industry, is proud to announce the third installment in the Viridian Cannabis Investment Series. Investing in the Emerging Cannabis Industry While Managing Risk, is an event that marks the first-ever cannabis investment conference in Florida.

This private event will explore the opportunities and risks in this growing multi-billion-dollar industry and will feature presentations and networking sessions with leading companies, investors, scientists, and thought leaders from the following sectors: Real Estate, Security, Biotech, Cultivation & Retail, AgTech, Lab Testing, Consumption Devices, Infused Products, and Digital Media.


High Times Cannabis Cup – (Clio, MI: June 11-12)

The High Times Michigan Medical Cannabis Cup is returning to the Auto City Speedway in Clio, Michigan for our first ever all-medical event! The event will only be open to medical patients with the entire festival zoned to medicate, but doctors will be available on site. Any state’s medical marijuana qualification is acceptable for admission.


Oregon Hemp Convention – (Portland, OR: June 11-12)

The Oregon Hemp Convention is an unbelievable opportunity for the entire cannabis industry to come together and introduce ourselves to the rush of new cannabis users in the state of Oregon.

With new and exciting legal option available for recreational consumers in the form of concentrates and edibles. Don’t miss out on this great opportunity to introduce yourself to the Oregon public and scope out the finest cannabis Oregon has to offer for yourself!

IMPACT: Brain Health and Cannabis

IMPACT: Brain Health and Cannabis – (Denver, CO: June 12)

The monthly IMPACT Network conference will be on Brain Health & Cannabis Sunday, June 12th, from noon to 5 pm at Green Labs in Denver’s RiNo district. Patients, caregivers, healthcare professionals, and industry leaders are all welcome.

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CannabisNowMagazine.com: Top Cannabis Tech Companies

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